What is Ascent?

Ascent is an injectable solution designed to cushion, lubricate, and reduce inflammation in fluid environments, such as joints and tendons. It is derived from amniotic fluid, which contains natural components that support the growth and development of human anatomies. Using a patent-pending method for processing amniotic fluid, Ascent captures these unique components in a single solution. Ascent is offered in a range of sizes to suit a wide variety of applications including osteoarthritic joints and tendinopathies.


Why amniotic fluid?

Amniotic fluid surrounds a baby during pregnancy and has evolved over millenia to create the ideal environment for the creation of human anatomies. This complex fluid is a rich source of nutrients, cytokines, and growth factors that manage cellular activity. StimLabs receives amniotic fluid from full-term C-section mothers who agree to donate their amniotic fluid to help others. All donors comply with our extensive screening policy to ensure the fluid is safe for patient use. Using the patent-pending Selectify process, key components of this fluid are selected into a single injectable solution to revive joints and tendons.

Epidermal Growth Factor

Growth Factor Molecule

Growth Factor Molecule

How does it work?

Joints and tendons degrade over time from a range of factors including mechanical overloading, age, and genetics. These factors result in a complex series of biological events that cause inflammation and degradation. In joints, this causes cartilage breakdown and a change in synovial fluid composition. In tendons, this causes collagen breakdown and microdisruptions along the tendon sheath. Ascent contains native biomolecular components designed to counteract these effects in fluid environments to provide relief and revive the anatomical structures. Some of these components are below:

TIMP-1

TIMPs have been shown to downregulate MMP-13, which is a primary contributor to inflammation.1

IL-1ra

IL-1ra helps counteract cartilage degradation by downregulating IL-1 receptor expression.2

Hyaluronic Acid

Hyaluronic acid is a significant component of joint fluid that provides lubrication and cushioning.


1. Li, et al. Upregulation of MMP-13 and TIMP-1 expression in response to mechanical strain in MC3T3-E1 osteoblastic cells. BMC Research Notes 2010, 3:309. 2. Palmer, et al. Production of interleukin-1 receptor antagonist by human articular chondrocytes. Arthritis Res. 2002;4(3):226-31.